博士，现任北京师范大学文理学院副教授、博士生导师；主持包括国家级和省部级等项目共计11项，发表高水平学术论文40余篇；任Exploration青年编委、Oncology and Translational Medicine学术编辑、细胞生物学学会、广东省生物医学工程学会、中国化学学会会员。

教育背景

2014.09-2017.06 暨南大学，生物材料与组织工程，工学博士

2011.09-2014.06 暨南大学，生物化学与分子生物学，理学硕士

2007.09-2011.06 西北农林科技大学，生物科学，理学学士

工作经历

2021.02-至今 北京师范大学 珠海校区，副教授

2020.03-2021.01 苏黎世联邦理工学院 博士后 （Martin Fussenegger）

2017.12-2019.12 南洋理工大学 博士后 （Xue-Wei Liu）

研究方向

合成生物学：工程化改造底盘细胞是合成生物学领域重要的研究内容，实验室将长期致力于改造不同底盘细胞，应用于肿瘤、细菌感染疾病和代谢性疾病的治疗。

纳米疫苗：多功能纳米递送系统在疾病精准治疗中发挥重要作用，实验室通过开发免疫相关细胞靶向型多功能纳米佐剂制备纳米疫苗，用于肿瘤和细菌感染疾病的防治。

科研项目

1. 国家自然科学基金委员会，2026-2029，主持

2. 北京市自然科学基金委，2026-2029，主持

3. 广东省青年基金项目，2023-2026，主持

4.广东省高校特色创新项目，2021-2024，主持

5.国家自然科学基金委员会，2018-2022，主持

代表论文

1. Shuihao Zhao, Yuyun Zhong, Shun Huang, Xinshuang Zou, Yuhan Wei, Xianxin Dong, Gao-Fei Du, Sha Li*, Kelong Fan*, Zhong Guo*. Engineered Mammalian Cell Membrane-Coated Nanoparticles for Targeted Delivery of Antibiotics to Eradicate Drug-Resistant Gram-Negative Bacteria. Advanced Functional Materials., 2026.

2. Ningyue Yu, Shengze Lu, Bing Xiao*, Zhong Guo*, Jingchao Li*. Molecularly nanoengineered dendritic cells for tumor-specific antigen capture and sono-activatable cytokine-mediated immunotherapy. Biomaterials., 2026.

3. Zheming Song, Li Li, Anni Zhu, Danling Cheng, Yuyun Zhong, Zhiming Zheng*, Cong Song*, Jingchao Li*, Zhong Guo*. Tumor microenvironment-triggered aggregation of semiconducting polymer nanochangers for self-programable theranostics of orthotopic glioma. Theranostics., 2026.

4. Haolun Gu, Jingqi Li, Pengyu Dai, Tiedong Sun*, Chunxia Chen*, Zhong Guo*, Kelong Fan*. Polyphenol Oxidase-Like Nanozymes. Advanced Materials., 2025.

5. Linghong Huang, Xinyuan Sun, Ting Song, Jun long, Xuewu Chen, Renfeng Dong, Zonghua Liu*, Zhong Guo*. The swarmable magnetic-driven nanorobots for facilitating trans-intestinal mucosal delivery of oral vaccines to enhance mucosal and systemic immune response. Nano Today., 2025,

6. Yue Liu, Fei Li, Yan Lyu*, Fengshuo Wang, Leo Tsz On Lee*, Shasha He*, Zhong Guo*, Jingchao Li*. A Semiconducting Polymer NanoCRISPR for Near-Infrared Photoactivatable Gene Editing and Cancer Gene Therapy. Nano Letters. 2025, Mar 7.

7. Ting Song, Nan Li, Qinhua Zuo, Linghong Huang*, Zonghua Liu*, Zhong Guo*. Mucus-penetrating nanomotor system strengthens mucosal immune response to in situ bacterial vaccine against severe bacterial pneumonia. Biomaterials. 2025, 320: 123236.

8. Shuangquan Lai, Boling Cao, Xumei Ouyang, Shuting Zhang, Jing Li, Wenhuan He, Jianwen Dong, Liangjie Shi, Yau Kei Chan, Zhong Guo*, Yi Deng*, Shaojun Peng*. Fluorescent Microneedle-Based Theranostic Patch for Naked-Eye Monitoring and On-Demand Photo-Therapy of Bacterial Biofilm Infections. Advanced Functional Materials. 2024, 2415559.

9. Shun Huang, Shuihao Zhao, Haijie Zhao, Mingzhang Wen*, Zhong Guo*. Synthetic Biology-Based Engineering Living Therapeutics for Antimicrobial Application. Exploration. 2024, 20240045.

10. You-Bo Yu, Ying Liu, Hangeri Liang, Xianxin Dong, Xiao-Yan Yang*, Sha Li*, Zhong Guo*.  A Nanoparticle-based Anti-Caries Vaccine Enhances the Persistent Immune Response to Inhibit Streptococcus mutans and Prevent Caries. Microbiology Spectrum. 2023 Mar 28:e0432822.

11. You-Bo Yu, Ying Liu, Sha Li, Xiao-Yan Yang*, Zhong Guo*.  The pH-responsive zeolitic imidazolate framework nanoparticle as a promising immune-enhancing adjuvant for anti-caries vaccine. Journal of Dentistry. 2023, 130, 104413.

12. Yunxi Du, Zhong Guo*. Recent progress in ferroptosis: inducers and inhibitors. Cell Death & Discovery. 2022. Dec. 19.

13. Xin Cao^#, Zhong Guo^#, Hualong Wang, Yuelei Dong, Songhui Lu, Qing-Yu He*, Xuesong Sun*, Gong Zhang*. Autoactivation of translation causes the bloom of Prorocentrum Donghainese in harmful algal blooms. Journal of Proteome Research. 2021, 20(6):3179-3187.

14. Zhong Guo, Sha Li, Yangchun Qu, Wei Xue, Xifei Yu*, Zonghua Liu*. Bio-membrane adhesive poly(choline phosphate L-glutamate)-based nanoparticles as vaccine delivery systems for cancer immunotherapy. Chemical Engineering Journal. 2021, 417, 127970.

15. Yi Li, Zhong Guo*, Sha Li, Bart Van der Bruggen*. Interfacially Polymerized Thin Film Composite Membranes for Organic Solvent Nanofiltration. Advanced Materials Interfaces. 2021, 8, 2001671.

16. Yi Li, Junyong Zhu*, Sha Li, Zhong Guo*, Bart Van der Bruggen*. Flexible Aliphatic-Aromatic Polyamide Thin Film Composite Membrane for Highly Efficient Organic Solvent Nanofiltration. ACS Applied Materials & Interfaces., 2020, 12(28), 31962-31974.

17. Zhong Guo, Jingxi He, Surendra H. Mahadevegowda, Kho Shu Hui, Mary B. Chan-Park*, and Xuewei Liu*. Multifunctional Glyco-Nanosheets to Eradicate Drug-Resistant Bacteria on Wounds. Advanced Healthcare Materials., 2020, 9(10), 202000265.

教学工作

本科生： 免疫学、细胞生物学

研究生： 合成生物学、合成生物学前沿