博士，现任北京师范大学文理学院生物系副主任，副教授、博士生导师；主持国家级项目2项，省部级项目2项，发表高水平学术论文30余篇；任Exploration青年编委、Oncology and Translational Medicine学术编辑、细胞生物学学会、广东省生物医学工程学会、中国化学学会会员；担任Advanced Materials等高水平学术期刊审稿人。

教育背景

2014.09-2027.06 暨南大学，生物材料与组织工程，工学博士

2011.09-2014.06 暨南大学，生物化学与分子生物学，理学硕士

2007.09-2011.06 西北农林科技大学，生物科学，理学学士

工作经历

2021.02-至今 北京师范大学 珠海校区，副教授

2020.03-2021.01 苏黎世联邦理工学院 博士后 （Martin Fussenegger）

2017.12-2019.12 南洋理工大学 博士后 （Xue-Wei Liu）

研究方向

合成生物学：工程化改造底盘细胞是合成生物学领域重要的研究内容，实验室将长期致力于改造不同底盘细胞，应用于肿瘤、细菌感染疾病和代谢性疾病的治疗。

纳米疫苗：多功能纳米递送系统在疾病精准治疗中发挥重要作用，实验室通过开发免疫相关细胞靶向型多功能纳米佐剂制备纳米疫苗，用于肿瘤和细菌感染疾病的防治。

科研项目

1. 国家自然科学基金委员会；靶向树突状细胞的铜绿假单胞菌环状RNA纳米疫苗的保护效果及机制研究；2026-2029；主持

2. 广东省青年基金项目；合成纳米生物学用于革兰氏阴性耐药菌感染的治疗；2023-2026；主持

3.广东省高校特色创新项目：基于合成生物学设计的工程化哺乳动物细胞用于革兰氏阴性菌感染疾病的治疗和预防；2021-2024；主持

4.国家自然科学基金委员会；靶向多肽功能化的智能响应型疫苗佐剂递送龋齿抗原用于龋齿的防治；2018-2022；主持

发表论文

1. Haolun Gu, Jingqi Li, Pengyu Dai, Tiedong Sun*, Chunxia Chen*, Zhong Guo*, Kelong Fan*. Polyphenol Oxidase-Like Nanozymes. Advanced Materials., 2025.

2. Linghong Huang, Xinyuan Sun, Ting Song, Jun long, Xuewu Chen, Renfeng Dong, Zonghua Liu*, Zhong Guo*. The swarmable magnetic-driven nanorobots for facilitating trans-intestinal mucosal delivery of oral vaccines to enhance mucosal and systemic immune response. Nano Today., 2025.

3. Yue Liu, Fei Li, Yan Lyu*, Fengshuo Wang, Leo Tsz On Lee*, Shasha He*, Zhong Guo*, Jingchao Li*. A Semiconducting Polymer NanoCRISPR for Near-Infrared Photoactivatable Gene Editing and Cancer Gene Therapy. Nano Letters. 2025, Mar 7.

4. Ting Song, Nan Li, Qinhua Zuo, Linghong Huang*, Zonghua Liu*, Zhong Guo*. Mucus-penetrating nanomotor system strengthens mucosal immune response to in situ bacterial vaccine against severe bacterial pneumonia. Biomaterials. 2025, 320: 123236.

5. Shuangquan Lai, Boling Cao, Xumei Ouyang, Shuting Zhang, Jing Li, Wenhuan He, Jianwen Dong, Liangjie Shi, Yau Kei Chan, Zhong Guo*, Yi Deng*, Shaojun Peng*. Fluorescent Microneedle-Based Theranostic Patch for Naked-Eye Monitoring and On-Demand Photo-Therapy of Bacterial Biofilm Infections. Advanced Functional Materials. 2024, 2415559.

6. Shun Huang, Shuihao Zhao, Haijie Zhao, Mingzhang Wen*, Zhong Guo*. Synthetic Biology-Based Engineering Living Therapeutics for Antimicrobial Application. Exploration. 2024, 20240045.

7. You-Bo Yu, Ying Liu, Hangeri Liang, Xianxin Dong, Sha Li*, Xiao-Yan Yang*, Zhong Guo*.  A Nanoparticle-based Anti-Caries Vaccine Enhances the Persistent Immune Response to Inhibit Streptococcus mutans and Prevent Caries. Microbiology Spectrum. 2023 Mar 28:e0432822.

8. You-Bo Yu, Ying Liu, Sha Li, Xiao-Yan Yang*, Zhong Guo*. The pH-responsive zeolitic imidazolate framework nanoparticle as a promising immune-enhancing adjuvant for anti-caries vaccine. Journal of Dentistry. 2023, 130, 104413.

9. Yunxi Du, Zhong Guo*. Recent progress in ferroptosis: inducers and inhibitors. Cell Death & Discovery. 2022. Dec. 19.

10. Zhong Guo, Sha Li, Yangchun Qu, Wei Xue, Xifei Yu*, Zonghua Liu*. Bio-membrane adhesive poly(choline phosphate L-glutamate)-based nanoparticles as vaccine delivery systems for cancer immunotherapy. Chemical Engineering Journal., 2021, 417, 127970.

11. Zhong Guo, Jingxi He, Surendra H. Mahadevegowda, Kho Shu Hui, Mary B. Chan-Park*, and Xuewei Liu*. Multifunctional Glyco-Nanosheets to Eradicate Drug-Resistant Bacteria on Wounds. Advanced Healthcare Materials., 2020, 9(10), 202000265.

12. Zhong Guo, Sha Li, Zonghua Liu*, Wei Xue*. Tumor-Penetrating Peptide-Functionalized Redox-Responsive Hyperbranched Poly(amido amine) Delivering siRNA for Lung Cancer Therapy. ACS Biomaterial Science & Engineering., 2018, 4(3), 988-996.

13. Meng Lv, Sha Li, Haijie Zhao, Kewei Wang, Qianqian Chen, Zhong Guo*, Zonghua Liu* and Wei Xue*. Redox-responsive hyperbranched poly(amido amine) and polymer dots as a vaccine delivery system for cancer immunotherapy. Journal of Materials Chemistry B., 2017, 5, 9532-9545.

14. Zhong Guo^#, Sha Li^#, Zonghua Liu*, and Wei Xue*. Redox-responsive biodegradable PAA used for intranasal antigen delivery systems. ACS Biomaterial Science & Engineering., 2017, 3 (10), 2420–2430.

教学工作

本科生： 免疫学、细胞生物学

研究生： 合成生物学、合成生物学前沿