个人信息简介
姓名:秦志伟 学历:研究生 职称:特聘研究员 电子邮箱:z.qin@bnu.edu.cn
博士毕业于英国阿伯丁大学,之后在英国久负盛名的约翰英纳斯中心(John Innes Centre)从事博士后研究工作,主要研究方向是微生物天然产物。2020年加入北京师范大学,目前担任文理学院院长助理,生物系特聘研究员,博士生导师,主要从事先进人工智能技术和生物医药的交叉,致力于开发新型生防菌、抗生素和除草剂等。目前,在Nature Communications, Chemical Science, Plant Physiology,Journal of Advanced Research,Critical Reviews等刊物发表论文30余篇,主持国家自然科学基金、广东省自然科学基金多项,2022年入选广东省“珠江人才计划”。课题组官网:www.zhiweiqin.com
教育背景
2004.09-2008.06 郑州大学,制药工程,工学学士
2009.09-2011.06 阿伯丁大学,有机化学,理学硕士
2011.07-2013.11 阿伯丁大学,有机化学,理学博士
工作经历
2013年12月-2017年2月,英国约翰英纳斯中心,博士后
2017年2月-2018年2月,英国东安格利亚大学,博士后
2018年2月-2019年8月,英国约翰英纳斯中心,博士后
2019年9月-2020年8月,英国Demuris生物科技公司,研究员
2020年10月-2023年11月,北京师范大学自然科学高等研究院,特聘研究员,博士生导师
2023年12月-至今,北京师范大学文理学院,院长助理,特聘研究员,博士生导师
研究方向
1. 微生物天然产物的探索与应用
2. 人工智能与生物医药的结合
3. 生防菌的开发与应用
4. 新型抗生素的研发
5. 新型除草剂的开发
科研项目
1. 国家自然科学基金面上项目;2022-2025;主持
2. 广东省自然科学基金面上项目;2021-2023;主持
3. 广东省自然科学基金面上项目;2024-2026;主持
4. 广东省粤澳青年人才双向交流项目;2022-2023;主持
发表论文
1. H. Zhang*, Y. Wu#, Y. Zhu#, L. Ge, J. Huang*, Z. Qin*. Identification and functional analysis of a serine protease inhibitor using machine learning strategy. International Journal of Biological Macromolecules. 2024,
2. H. Zhang, Y. Wang, P. Huang, Y. Zhu, X. Li, Z. Chen, Y. Liu, J. Jiang, Y. Gao, J. Huang*,Z. Qin*. Machine learning and genetic algorithm-guided directed evolution for the development of antimicrobial peptides.Journal of Advanced Research,2024
3. J. Huang#, Y. Wu#, Q. Gao, X. Li, Y. Zeng, Y. Guo, H. Zhang*,Z. Qin*. Metagenomic exploration of the rhizosphere soil microbial community and their significance in facilitating the development of wild simulated ginseng.Applied Environmental Microbiology, 2024.
4. X. Zhan, X. Li, Y. Zeng, S. Jiang, C. Pan, S. Pan, J. Huang*, H. Zhang*,Z. Qin*. Unlocking the biosynthetic regulation role of polyketide alkaloid lydicamycins.New Journal of Chemistry, 2024, 48, 525-528.
5. J. Huang#, X. Li#, X. Zhan#, S. Pan, C. Pan, J. Li, S. Fan, L. Zhang, K. Du, Z. Du, J. Zhang, H. Huang, J. Li, H. Zhang*,Z. Qin*. A Streptomyces species from the ginseng rhizosphere exhibits biocontrol potential.Plant Physiology, 2024, kiae006.
6. J. Huang, Q. Gao, Y. Tang, Y. Wu, H. Zhang*,Z. Qin*. A deep learning model for type II polyketide natural product prediction without sequence alignment.Digital Discovery, 2023, 2, 1484-1493.
7. H. Zhang, X. Li, S. Pan, J. Huang*,Z. Qin*. Dissecting the biosynthesis of the polyketide alkaloid lydicamycin using a complex metabolic network.New Journal of Chemistry, 2023, 47, 12093-12100.
8. C. Pan, Y. Zhu, K. Cao, J. Li, S. Wang, J. Zhu, X. Zeng, H. Zhang*,Z. Qin*. Transcriptome, intestinal microbiome and histomorphology profiling of differences in the response of Chinese sea bass (Lateolabrax maculatus) to Aeromonas hydrophila infection.Frontiers in Microbiology, 2023, 14:1103412.
9. M. A. Farag*, B. Abib,Z. Qin*, X. Ze, S. E. Ali. Dietary macrominerals: updated review of their role and orchestration in human nutrition throughout the life cycle with sex differences.Current Research in Food Science, 2023, 6, 100450.
10. C. Yang#, W. Xie#, H. Zhang#, W. Xie, T. Tian* andZ. Qin*. Recent two-year advances in anti-dengue small-molecule inhibitors.European Journal of Medicinal Chemistry, 2022, 243, 114753.
11. T. Tian#, H. Cao#, M. A. Farag, S. Fan, L. Liu, W. Yang, Y. Wang, L. Zou, K. Cheng, M. Wang, X. Ze, J. Simal-Gandara*, C. Yang* andZ. Qin*. Current and potential trends in the bioactive properties and health benefits of Prunus mume Sieb. Et Zucc: A comprehensive review for value maximization.Critical Reviews in Food Science and Nutrition, 2023, 63, 7091-7107.
12. T. Tian#, W. Xie#, L. Liu, S. Fan, H. Zhang,Z. Qin* and C. Yang*. Industrial application of antimicrobial peptides based on their biological activity and structure-activity relationship.Critical Reviews in Food Science and Nutrition, 2023, 63, 5430-5445.
13. Y. Wu, Y. Yang, H. Dang, H. Xiao, W. Huang, Z. Jia, X. Zhao, K. Chen, N. Ji, J. Guo,Z. Qin, J. Wang and J. Zou. Molecular identification of Klebsiella pneumoniae and expression of immune genes in infected spotted gar Lepisosteus oculatus .Fish and Shellfish Immunology, 2021, 119, 220-230.
14. Z. Qin#, R. Devine#, T. J. Booth, E. H. E. Farrar, M. N. Grayson, M. I. Hutchings and B. Wilkinson. Formicamycin biosynthesis involves a unique reductive ring contraction.Chemical Science, 2020, 11, 8125-8131.
15. Z. Qin#, R. Devine#, M. I. Hutchings and B. Wilkinson. A role for antibiotic biosynthesis monooxygenase domain proteins in fidelity control during aromatic polyketide biosynthesis. 2019,Nature Communications, 2019, 10, 3611.
16. Z. Qin, J. T. Munnoch, R. Devine, N. A. Holmes, R. F. Seipke, B. Wilkinson and M. I. Hutchings. Formicamycins, antibacterial polyketides produced by Streptomyces formicae isolated from African Tetraponera plant-ants.Chemical Science, 2017, 8, 3218-3227.
教学工作
本科生:《微生物药物学》
研究生:《天然药物化学》,《高级生物学专题研讨》,《科学研究方法与素养》
荣誉获奖
1. 广东省“珠江人才计划”引进高层次人才
2. 广东省人才优粤卡(B类)