北京师范大学文理学院副教授，博士生导师。长期从事医学成像探针的研发与临床转化，致力于实现疾病的早期无创诊断和术中精准导航。通过先导化合物筛选，化学修饰和生物性质评价得到的两个放射性药物在临床上完成超过上千例病例与健康对照检查，从基础研究到临床转化迈出了重要一步。获得国际和国家发明专利授权多项，两项完成转化。目前聚焦于近红外二区（1000-1700 nm）荧光探针开发，开展从分子设计到活体实验的完整研究链条，成功突破了光稳定性，体内药代动力学和深层成像的瓶颈，研发了系列染料，推动了肿瘤术中导航，重要组织或器官的标记以及多色成像分析的发展。此外，将荧光技术与正电子技术的融合用于术前定位，术中导航。主持国家自然科学基金青年项目，北京市自然科学基金面上项目等基金。

教育背景

2010.09-2014.06  兰州大学，放射化学专业，理学学士

2014.09-2019.06  北京师范大学，放射性药物与分子工程，理学博士，导师：崔孟超教授。

工作经历

2019.10-2021.04  斯坦福大学，医学院放射性分子影像中心（MIPS），博士后，导师：Jianghong Rao教授

2021.04-2023.07  北京师范大学，自然科学高等研究院，特聘副研究员（青年英才）

2023.07-至今  北京师范大学，文理学院，副教授

研究方向

Probe Chemistry and Radiopharmaceutical Sciences

科研项目

1.国家自然科学基金青年项目，靶向于颗粒酶B的近红外荧光探针开发及其肿瘤免疫治疗显像研究，No.22107010，2022/01-2024/12；主持

2.北京市自然科学基金面上项目，基于D-π-A结构的肿瘤免疫治疗近红外成像探针设计及应用，No.2232009，2023/01-2025/12；主持

3.广东省普通高校青年创新人才类项目，激活型长波长ESIPT近红外荧光探针构建及其免疫治疗成像研究，No.2021KQNCX267，2022/01-2023/12；主持

4. 北京师范大学珠海校区引进人才工作运行和科研启动项目；2022-2024；主持

代表论文

(1) Yufei Qin, Yanling Luo, Jiaming Guo, Yonggang Liu, Yimin Chen, Yiling Zhu, Huiyan Zhang, Yuying Li, Hualong Fu, Xiaojiang Duan, Mengchao Cui, Kaixiang Zhou*, CCNJ and DCNJ are Bright Julolidine-Based Fluorescent Molecular Rotors, Sensors & Actuators: B. Chemical , 444 (2025), 138472.

(2) Yufei Qin, Yihan Xu, Xi Gao, Yujie Qin, Yiling Zhu, Jiaming Guo, Yimin Chen, Yuying Li, Tianbao Wang, Hualong Fu, Xiaojiang Duan, Menghchao Cui, Kaixiang Zhou*, Finely Tuned, Meticulously Screened Renal-clearable Zwitterionic Cyanine Dyes for Targeted NIR-II Tumor Detection, Intraoperative Navigation and Dual-color Imaging, Journal of Medicinal Chemistry , 2025, 68(13), 13954–13972

(3) Xi Gao, Jin-yu Wang, Yufei Qin, Yiling Zhu, Ya-jun Liu, Kaixiang Zhou^*, Mengchao Cui^*, Design, Synthesis and in vivo Imaging of a Stable Xanthene-based Dye with NIR-II Emission up to 1450 nm, Analytical Chemistry , 2025, 97(3), 1827–1836

(4) Tianbao Wang, Yufei Qin, Jin-yu Wang, Yihan Xu, Jiaming Guo, Yiling Zhu, Huiyan Zhang, Yujie Qin, Zhong-Quan Qi, Hualong Fu, Ya-jun Liu, Mengchao Cui, Kaixiang Zhou*, Less is More: Donor Engineering of a Stable Molecular dye for Bioimaging in the NIR-IIb Window, Journal of Medicinal Chemistry, 2025, 68(3), 3782–3794.

(5) Jiaming Guo, Yiling Zhu, Yuqian Qu, Longfei Zhang, Mingxi Fang, Zihan Xu, Tianbao Wang, Yufei Qin, Yihan Xu, Yuying Li, Yimin Chen, Hualong Fu, Xiayu Liu, Yajun Liu, Cheng Liu, Yuan Gao, Mengchao Cui, Kaixiang Zhou*, Structure Tailoring of Hemicyanine Dyes for in vivo Shortwave Infrared Imaging, Journal of Medicinal Chemistry, 2024, 67(18), 16820–16834.

(6) Yuying Li^#, Kaixiang Zhou^#, Xiaojun Zhang, Hailong Zhao, Xiaoming Wang, Ruilin Dong, Yan Wang, Baian Chen, Xiao-xin Yan, Jiapei Dai, Yanying Sui*, Jinming Zhang*, and Mengchao Cui*, Fluorine-18-LabeledDiaryl-azinesas Improved βAmyloid Imaging Tracers: From Bench to First-in-Human Studies, Journal of Medicinal Chemistry 2023, 66(7), 4603–4616. (^#these authors contributed equally to  this work)

(7) Min Chen^#, Kaixiang Zhou^#, Sheng-Yao Dai^#, Sirimuvva Tadepalli, Preethi Bala Balakrishnan, Jinghang Xie, Fadi E.I. Rami, Tingting Dai, Liyang Cui, Juliana Idoyaga, and Jianghong Rao,*, In vivo bioluminescence imaging of granzyme B activity in tumor response to cancer immunotherapy,   Cell Chemical Biology , 2022, 29 , 10 1556-1567.e6 (^#these authors contributed equally to  this work)

(8) Zhou Kaixiang; Yang Fan; Li Yuying; Chen Yimin; Zhang Xiaojun; Zhang Jinming; Wang Junfeng; Dai Jiapei; Cai Lisheng*; Cui Mengchao*; Synthesis and Evaluation of Fluorine-18 Labeled 2‑Phenylquinoxaline Derivatives as Potential Tau Imaging Agents, Molecular Pharmaceutics, 2021, 18(3): 1176-1195.

(9) Zhou, Kaixiang; Yuan, Chang; Dai, Bin; Wang, Kan; Chen, Yimin; Ma, Denglei; Dai, Jiapei; Liang, Yi*; Tan, Hongwei*; Cui, Mengchao*; Environment-Sensitive Near-Infrared Probe for Fluorescent Discrimination of Abeta and Tau Fibrils in AD Brain, Journal of Medicinal Chemistry, 2019, 62(14): 6694-6704.

(10) Zhou, Kaixiang; Li, Yuying; Peng, Yi; Cui, Xiaomei; Dai, Jiapei; Cui, Mengchao*; Structure-Property Relationships of Polyethylene Glycol Modified Fluorophore as Near-Infrared Abeta Imaging Probes, Analytical Chemistry, 2018, 90(14): 8576-8582.

教学工作

本科生： 药物化学，放射性药物与分子影像，基础合成实验I

指导本科生获奖情况：第十八届“挑战杯”广东大学生课外学术科技作品竞赛自然科学论文类省级二等奖以及三等奖；北京师范大学珠海校区第十八届“挑战杯”广东大学生课外学术科技作品竞赛校赛一等奖以及二等奖